The University of South Carolina (USC) Big Data Health Science Center (BDHSC), an interdisciplinary enterprise and one of the USC Excellence Initiatives established in 2019, promotes and supports big data health science research through capacity development, academic training, professional development, community engagement, and methodological advancement. Its five content cores (Artificial Intelligence for Sensing and Diagnosis, Electronic Health Records, Genomics, Geospatial, and Social Media) and two functional hubs (Business/Entrepreneurship and Technology) embody interdisciplinary collaboration and foster cutting-edge research and discovery. Our mission is to be an innovation-driven enterprise that can facilitate and accelerate a sustained, high-caliber transformation of the USC into a global leader in big data health science.