This project has received funding from the European Union’s Horizon 2020 Research and Innovation program under grant agreement No 871518. COLLABS will develop, validate, demonstrate, and support a comprehensive cyberintelligence framework for collaborative manufacturing, which enables the secure data exchange across the digital supply chain while providing a high degree of resilience, reliability, accountability and trustworthiness, and addresses threat prevention, detection, mitigation, and real-time response. COLLABS will achieve these goals by utilising state-of-the-art technologies and making significant scientific and technological advances in several key relevant domains, including secure multi-party computations and homomorphic encryption, distributed deep learning and anomaly detection, distributed ledger technologies (blockchain) and smart contracts, and distributed remote software attestation. COLLABS will significantly contribute to realising industrial and societal opportunities of collaborative manufacturing, by validating and demonstrating its framework on 3 real-world use cases coming from complementary Industry 4.0 manufacturing domains and delivering an Industry 4.0 Experimentation Lab.